Register for our Exhibitor Workshop:
Visualization of Patterns of Co-expression of Immune Checkpoint Markers in Non-small Cell Lung Cancer by RNAscope® Technology
Xiao-Jun Ma, PhD., Chief Scientific Officer, Advanced Cell Diagnostics, Inc.
Although cancer immunotherapy is changing the paradigm of how cancer is treated, there is an urgent need to develop predictive biomarkers to identify patients who are most likely to benefit from various immunotherapeutic strategies. Whereas many biomarker analysis technologies are available, most do not provide spatial and cell type-specific information critical for assessing the immune response in the evolving microenvironment of each tumor. Furthermore, multiplexing capabilities are highly desirable to obtain comprehensive, single-cell-level co-expression information and to maximize the use of limited biopsied sample material. Advanced Cell Diagnostics will demonstrate how the RNAscope technology for RNA in situ hybridization can be used to visualize various immune checkpoint markers directly, to reveal complex patterns of co-expression at single-cell resolution in morphological context.