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Join us in Washington
for IMMUNOLOGY 2017
May 12 - 16 | Booth #940

Register now for our Exhibitor Workshop

Visualization of Patterns of Co-expression of Immune Checkpoint Markers in Non-small Cell Lung Cancer by RNAscope® Technology

May 15, 10:00 - 10:45 AM
Exhibitor Workshop Room 2

Walter E. Washington Convention Center

 

Register for our Exhibitor Workshop:

Visualization of Patterns of Co-expression of Immune Checkpoint Markers in Non-small Cell Lung Cancer by RNAscope® Technology

Xiao-Jun Ma, PhD., Chief Scientific Officer, Advanced Cell Diagnostics, Inc.

Although cancer immunotherapy is changing the paradigm of how cancer is treated, there is an urgent need to develop predictive biomarkers to identify patients who are most likely to benefit from various immunotherapeutic strategies. Whereas many biomarker analysis technologies are available, most do not provide spatial and cell type-specific information critical for assessing the immune response in the evolving microenvironment of each tumor. Furthermore, multiplexing capabilities are highly desirable to obtain comprehensive, single-cell-level co-expression information and to maximize the use of limited biopsied sample material. Advanced Cell Diagnostics will demonstrate how the RNAscope technology for RNA in situ hybridization can be used to visualize various immune checkpoint markers directly, to reveal complex patterns of co-expression at single-cell resolution in morphological context.


Visit us at booth #940 and learn how we visualize data with RNAscope® Technology

What is missing from
your biomarker analysis?

Visualize tumor microenvironments (TMEs) with RNAscope® in situ hybridization technology; delivering unrivaled single-molecule sensitivity and specificity - even for targets like splice variants, highly homologous sequences, and short sequences including CAR-T cell or CRD/TCR clones. The assay has the capacity to reveal molecular and cellular interactions of tumor cells and the immune system. Visualization and quantification of gene expression within the morphological context across the tumor allows insights in the tumor heterogeneity.
  • Detect mRNAs and lncRNAs at single molecule sensitivity using the RNAscope® assay
  • Use Basescope™ to target specific splice junctions for aberrant alternative splicing in cancers
  • Identify point mutations or gene editing with the BaseScop™ assay
  • Characterize expression profiles of various checkpoint markers and therapeutic targets in the TME
  • Perform single cell analysis and glean morphological information in FFPE or frozen tissues
  • Carry out quantitative analysis of co-expression of multiple checkpoint molecules within the same cell

Check out some of our RNAscope® technology related publications in immunology research

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